For your basic 20 amp 12/2 romex type of circuit ( for receptacles for example ), you need to ensure each connection point ( wire nuts junctioning wire to wire, wire to the screw terminals to a receptacle, ) are mechanically sound and tight. Pretwisting 2 or more wires with a line mans pliers before applying a wire nut ( as well as using the correct sized wire nut , proper amount of stripped lead out on the wires ) is a good practice for ensuring tight, trouble free joints.
The same applies to other wire sizes, be it solid or stranded. With stranded unless you have side plates to lock on to devices, they need to be pigtailed in solid or have the proper crimp on ring or fork terminal connectors.
Most wire nuts are rated for 2 wire ( appropriately sized ) junctioned with no pretwist, provided you tighten the wire nut ( and i the process end up twisting the wire ).
Devices ( switches and receptacles ) should never be back stabbed, but wire wrapped clockwise on the screw terminal.
Of course if you apply more amps continuously than the wire is rated for ( 30 amps on a 20 amp rated wire for example ) you'll get insulation failure and probably a fire as well. So proper over current protection of the circuit is vital as well.