Yes they do. It is a regular maintenance item that a lot of us look past, until they fail. Depending on the make of the unit, the mfg will usually send you a whole new cartridge at no cost.
The other would be how old the water heater is, what else is being ran in the house that uses hot water, what the recovery time is for the water heater, if there is an issue that when you flush the toilet, the cold water pressure drops, but the hot water suddenly spikes.