?? Sure it will.
But there's no need to do it. The adhesive itself can fill in any inconsistencies in the drywall. If you're tiling over a tapered drywall joint, just make sure to hold the trowel edges fully over the joint, to completely fill it in. If you're working with a small mosaic, this is probably the only time I'd fill in a tapered joint. But this is not going to be very common in a backsplash situation anyway. If you did want to prefill that joint with something, you could do it with one coat of joint compound, or even the tile adhesive, and then let that dry first.