Need more info. Is this on a first floor, or do you have an attic above it. If no attic, you will most likely have to cut sections to run the wire along the joist bays up in the ceiling. If going across, will best do it near where another light will be up in the ceiling to alleviate making a bunch of holes and patch. Really easy way is to just rip down the ceiling and go that route if doing a really old home.
Thanks for the advice everyone.Yes. Make sure when you cut the panels, do it on the joists and use a straight edge. Helps to have a helper or use a laser line to give you a straight line. Now if you have popcorn, or Orange peel texture on your ceiling, it will never look the same when you get done, so try to use the holes where you putting the lights up to pull the wire through. Figure if you take your time, you can use a Saturday, and always get everyone out of the house when you do it, or do it during the week when everyone else is at work or school, so you have the house to yourself.