I've painted my vans a few times a with waterborne DTM using an airless. It can be done with an oil based industrial enamel, but its tricky. bett not use annything bigger than a 410 tip though. 308 would be better. I also used satin to keep the imperfections from popping out as much.
If you want it professional looking, no.
I freelance repainted a bunch of semittrucks and trailers for a concrete cutting company for a bit, and I ended up using my airless to spray the primer, and to spray the frames black, because it didnt matter too much if I put it on too thick there. They were work vehicles that would get concrete slurry all over them anyway. The cabs and stuff I used a gravity feed cup gun. I was using a three part Nason product.
I did use my airless to spray a huge water trailer. It ran a few times though. I layed it off with a foamy roller. Like I said, construction equipment....
Oh, ans as a side note. I've poainted my vans with DTM acrylic, waterborne urethane Aquacron, and another oil based PPG product. The black stripe I did down the side of my van with Rustoleum from a quart can, is by far the most durable and sheen holding out of all of them. If I could get it in custom colors I would redo my van with rustoleum right now.