GM , you may get by without 1/4 round if you space very carefully depending on the thickness of your baseboards, but if you have carpet now the lower edge of the baseboards will likely be an eyesore. Recently I have come across really professional nice looking trim in new homes done with 1 x 1/4 door jamb material turned on edge instead of 1/4 round.
Just a thought, run a bead of foam insulation at floor level while the baseboard if off, or under the baseboard if you are not removing it.
As for breaks in the job, doorways were not an inssue but breaks for coffee, snacks and Miller Time are mandatory to give the knees a rest.
If you are replacing carpet, save a chunk of underpad and double it up under your knees:thumbsup: