Couple ways
You could come out of the trunk line end cap with round and run it to the end of the basement go under then back up and run tight to the ceiling down the side that way you would not be cutting any supports and will still maintain your flow and the only low spot would be the end of the basement you could box out.
Another way is to transition to oval duct to cut down on the hole height giving you more strength, I would also cut blocks to fit next to the hole to give more support to the beam you are cutting.
You could come out of the trunk line end cap with round and run it to the end of the basement go under then back up and run tight to the ceiling down the side that way you would not be cutting any supports and will still maintain your flow and the only low spot would be the end of the basement you could box out.
Another way is to transition to oval duct to cut down on the hole height giving you more strength, I would also cut blocks to fit next to the hole to give more support to the beam you are cutting.