True center?
Not the tile expert here, but have done a lot of acoustical ceilings. The layout is similar, and Sammy gives good advice. I try to get the "borders" as even as possible. In your situation, you might "hide" a narrow row of tiles under the toe kick of the cabinet (if using one), behind the commode area, etc. With several offsets, make the "odd" border in the smallest area possible.
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