You could have all cream downstairs and up the stairway stopping at the hall and everything on 2nd floor including the hallway in the white (both are good color choices for woodwork). That would be my choice if I had two colors of painted woodwork.
In my opinion those coming into the house downstairs (especially people not living there) are more likely to notice two colors in view. More than likelly that would be the mingling area for company or visitors. Those living in the house and seeing it every day will not even notice any of it after awhile.
Good luck with your choice.