Well, first off, are you on a septic system or community waste drain?
You can run a 3" line down through the wall for the drains, using a sanitary tee at the second floor, and continue it up for the vent. Otherwise, you can use a sturdivent inside the attic space somewhere. You can also run water lines up through the walls to the upstairs, 1/2" pex should be adequate since you will not have a shower. You can rent crimp tools for pex piping to make your connections. However, be careful when you solder the water stops on the copper leads though, to much heat will melt the pex at the connection causing a leak.