I'm sure this is a little late in the project, but here goes.
When using metal studs, I install 1/2" ply at the base to nail the trim into. I also add wood 2x4's around the doors and windows so I can nail the trim on.
Trim screws will work on painted moldings. Not so well on stained.
"They that can give up essential liberty to obtain a little temporary safety deserve neither liberty nor safety."
B. Franklin 1759
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